Postdoctoral Research on tRNA Epigenetic Biology


米国Thomas Jefferson大学のYa-Ming Hou教授がポスドクを募集しています。Hou博士は明るく温かいお人柄で、日本人のポスドクも何人もいたことがあるので、働きやすいと思います。Thomas Jefferson 大学は、フィラデルフィアの中心部(自由の鐘のすぐそば)にあり、住むのには安全で便利な場所です。より詳しく聞きたい方は、直接Hou教授にご連絡されるか(ya-ming.hou[at]、東京都立大学理学部生命科学科准教授 安藤香奈絵(k_ando[at]まで。

Postdoctoral positions are available with Professor Ya-Ming Hou at Thomas Jefferson University, Sidney Kimmel Medical College. We focus on tRNA epigenetic changes and explore their roles in gene expression at the codon level and in response to cellular stress, which are new concepts at the cutting edge of molecular biology and central dogma. We use a synthetic biology approach with CRISPR/Cas-edited genomes to determine how modifications in tRNA impact cell fitness at the codon level. Our lab is intellectually stimulating and encouraging global networking. 

Current projects are tRNA epigenetic biology:

  • In response to environmental stress
  • In discovery of new bacterial physiology and antibiotic therapeutics
  • In neurodegenerative diseases.

For more information, please see the following publications and our website:

Cell Systems, 8, 302-314 (2019). PMID: 30981730 (Featured in Faculty 1000 Prime)
Nucleic Acids Res. 46, e37 (2018). PMID: 29361055
Nucleic Acids Res. 45, 4081-4093 (2017). PMID: 27956502
PNAS 113, 15096-15101 (2016). PMID: 27849575 (Featured in PNAS commentary)
Nat Struct Mol Biol, 10, 941-948 (2016). PMID: 27571175. (Featured in Science)
Nature Communications, 6:7226 (2015). PMID: 26009254
Chem and Biol (Cell Press) 21, 1351-1360 (2014). PMID: 25219964
Nature 510, 507-511 (2014). PMID: 24919148 (Featured in Nature News and Views)
Nat. Communications. 2:329 (2011). PMID: 21629262

Candidates with a recent Ph.D. and a passion for basic research are encouraged to apply. Experience in RNA-seq, high-throughput data analysis, fluorescence microscopy, cell culture, molecular biology, protein enzymology, nucleic acids research, and mitochondrial research is preferred.

Please send a cover letter, CV, and names and contact information of three references to:

Ya-Ming Hou
Professor of Biochemistry and Mol Biology
Thomas Jefferson University
233 S. 10th Street, BLSB 220
Philadelphia, PA 19107, USA
T: 215-503-4480
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