Postdoctoral Research on tRNA Epigenetic Modifications


米国フィラデルフィアのトマスジェファーソン大学のYa-Ming Hou博士の研究室で、ポスドクを募集しています。Hou博士はとても温かいお人柄で、日本人のポスドクも何人かいたことがあり、働きやすい研究室だと思います。トマスジェファーソン大学は、フィラデルフィアの中心部にあり、安全で便利な住みやすい場所です。興味のある方は、Hou博士に、カバーレターとCV, 推薦者3人の連絡先をお送りください。

Postdoctoral positions are available in the lab of Professor Ya-Ming Hou at Thomas Jefferson University, Sidney Kimmel Medical College. We focus on tRNA epigenetic modifications and explore their roles in gene expression at the codon level and in response to cellular stress, which are new concepts at the cutting edge of molecular biology. We use a synthetic biology approach to determine how modifications impact cell fitness in engineered genomes with synonymous replacement of codons.

Our lab is intellectually stimulating and encouraging global networking. Current projects are:

  • Codon-specific translation in response to stress.
  • Epigenetics of tRNA in neurodegenerate diseases.

For more information, please see the following publications and our website:

Cell Systems, 8, 302-314 (2019). PMID: 30981730 (Featured in Faculty 1000 Prime)
Nucleic Acids Res. 46, e37 (2018). PMID: 29361055
Nucleic Acids Res. 45, 4081-4093 (2017). PMID: 27956502
PNAS 113, 15096-15101 (2016). PMID: 27849575 (Featured in PNAS commentary)
Nat Struct Mol Biol, 10, 941-948 (2016). PMID: 27571175. (Featured in Science)
Nature Communications, 6:7226 (2015). PMID: 26009254
Chem and Biol (Cell Press) 21, 1351-1360 (2014). PMID: 25219964
Nature 510, 507-511 (2014). PMID: 24919148 (Featured in Nature News and Views)
Nat. Communications. 2:329 (2011). PMID: 21629262

Candidates with an expected Ph.D. and a passion for basic research are encouraged to apply. Experience in RNA-seq, high-throughput data analysis, fluorescence microscopy, cell culture, molecular biology, protein enzymology, nucleic acids research, and mitochondrial research is preferred.

Please send a cover letter, CV, and names and contact information of three references to:

Ya-Ming Hou
Professor of Biochemistry and Mol Biology
Thomas Jefferson University
233 S. 10th Street, BLSB 220
Philadelphia, PA 19107, USA
T: 215-503-4480
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