Postdoctoral Research on Epigenetics of tRNA at Thomas Jefferson University

2018年11月19日

Postdoctoral positions are available in the lab of Dr. Ya-Ming Hou at Thomas Jefferson University, Sidney Kimmel Medical College.

We study epigenetic post-transcriptional modifications of tRNA and how they impact codon-specific translation in diseases. Codon-specific translation is a new mechanism that regulates gene expression at the codon level and it is activated or repressed by stress. Current projects are:

(1)   Codon-specific translation in response to stress.

(2)   Epigenetics of tRNA in neurodegenerate diseases.

For more information, please see the following publications and our website:

Nucleic Acids Res. 45, 4081-4093 (2017). PMID: 27956502

PNAS113, 15096-15101 (2016). PMID: 27849575 (Featured in PNAS commentary)

Nat Struct Mol Biol, 10, 941-948 (2016).PMID: 27571175.(Featured in Science)

Nature Communications, 6:7226 (2015). PMID: 26009254

Chem and Biol(Cell Press) 21, 1351-1360 (2014). PMID: 25219964

Nature510, 507-511 (2014). PMID: 24919148 (Featured in Nature News and Views)

Nat. Communications. 2:329 (2011). PMID: 21629262

https://www.jefferson.edu/university/research/researcher/researcher-faculty/hou-laboratory.html

Candidates with an expected or recent Ph.D. and a strong research track record are encouraged to apply. Experience in RNA-seq, high-throughput data analysis, fluorescence microscopy, cell culture, molecular biology, protein enzymology, nucleic acid research, and mitochondrial research is preferred.

Please send a cover letter, CV, and names and contact information of three references to:

Ya-Ming Hou

Professor of Biochemistry and Mol Biology

Thomas Jefferson University

233 S. 10th Street, BLSB 220

Philadelphia, PA 19107, USA

T: 215-503-4480

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