Function and biogenesis of alternatively-processed microRNAs Integrator complex-mediated RNA processing and gene regulation
Postdoc salary starts at $47,476 per year.
1. Cover letter stating: laboratory experience in RNA/protein biochemistry and bioinformatics; your long-term career goals; date of availability to begin postdoc
2. Curriculum vitae (including publications and awards/honors)
3. List of at least three references
Dr. Mingyi Xie was trained in the laboratory of Dr. Joan Steitz at Yale University (2010-2016), where he documented two surprising microRNA (miRNA) biogenesis pathways:
- Herpesvirus saimiri (HVS)-miRNAs are processed by the host Integrator complex, a 14-subunit complex best known for executing the 3′-end cleavage of cellular small nuclear RNAs (snRNAs) (Cazalla, Xie and Steitz-Molecular Cell-2011; Xie et al.,-Genes & Development-2015).
- Mammalian m7G-capped precursor miRNAs are generated from RNA polymerase (Pol) II transcription start sites. Whereas the nuclear-cytoplasmic export of capped pre-miRNAs is mediated by Exportin-1 (Xie et al.,-Cell-2013; Xie and Steitz-RNA Biology-2014).
The Xie lab’s immediate research goal is to further delineate the unique modes of miRNA production (Sheng et al.,-Nucleic Acids Res.-2018), including Integrator-mediated RNA metabolism, and understand the functions of these special miRNAs in herpesviruses and their hosts. Such research will allow the design of therapies for related oncogenic herpesviruses and cancers. Visit https://xie.biochem.med.ufl.edu/ for more information.
University of Florida (UF) is a vibrant intellectual community with many cross-disciplinery interactions. UF is ranked top-10 public university in the United States. Gainesville is a delightful and family-friendly city that is one and a half hours away from major cities like Orlando, Jacksonville and Tampa Bay.