We seek highly motivated postdoctoral scientists (experimental and computational) to investigate the genome regulatory events that drive developmental decisions and their expression. The project is a collaboration between the laboratories of Julie Ahringer (Gurdon Institute) and John Marioni (Cambridge CRUK Institute).

The research will use the powerful model organism C. elegans to uncover general principles of eukaryotic chromatin regulation. Combining single-cell profiling with the invariant lineage of C. elegans makes it feasible to determine the locus-specific regulation of chromatin, gene expression, and nuclear organisation in every single cell as development proceeds from the zygote to the differentiated state. The project will use single cell profiling and super-resolution microscopy to follow specific developmental trajectories across the entire life of the animal. The computational component will explore the use of factor analysis models for integrating the multifaceted datasets.

For more information and to apply: